[Renal excretion of amino acids in chronic renal failure and in chronically dialyzed patients].

The authors investigated the renal amino acid (AK) excretion in patients having regular dialyzation treatment (PDL). It was revealed that the excretory fraction (EF) of all amino acids with the exception of taurine (Tau) increases, while there is a marked reduction of the working number of nephrons. The increase of the EF of amino acids in relation to the drop of Cin can be characterized by hyperbolic relationships. The increase of EF of amino acids by residual nephrons is obviously the result of a number of pathological processes. In some amino acids the increase of their EF is due to a rise of their serum concentration and the so-called "overflow" mechanism is involved. In others obviously their tubular transport is involved and this applies in particular to essential amino acids. In patients with regular dialyzation treatment the author found changes of the plasma levels of some amino acids even when the protein intake was not restricted. Changes in the EF of amino acids by residual nephrons of dialyzed patients are essentially of the same character as in non-dialyzed patients. Dialysis alone does not lead to important changes in the EF of amino acids.