免疫复合物作为自身免疫性疾病的治疗方法。
Immune complexes as therapy for autoimmunity.
作者信息
Clynes Raphael
机构信息
Department of Medicine and Microbiology, Columbia University, New York, New York 10032, USA.
出版信息
J Clin Invest. 2005 Jan;115(1):25-7. doi: 10.1172/JCI23994.
Abstract
For several decades, intravenous Ig has been used as treatment for a variety of immune-related diseases, including immune thrombocytopenic purpura (ITP), autoimmune neuropathies, systemic lupus erythematosus, myasthenia gravis, Guillain-Barré syndrome, skin blistering syndromes, and Kawasaki disease. Despite years of use, its mechanism of immunomodulation is still unclear. Recent studies using mouse models of ITP and arthritis, including one reported in this issue of the JCI, now provide some insights into this mechanism and the rationale for the development of Fcgamma receptor-targeted therapeutics.
摘要
几十年来，静脉注射免疫球蛋白一直被用作治疗多种免疫相关疾病，包括免疫性血小板减少性紫癜（ITP）、自身免疫性神经病、系统性红斑狼疮、重症肌无力、吉兰-巴雷综合征、皮肤水疱综合征和川崎病。尽管使用了多年，其免疫调节机制仍不清楚。最近使用ITP和关节炎小鼠模型进行的研究，包括本期《临床研究杂志》报道的一项研究，现在为这种机制以及开发靶向Fcγ受体的疗法的基本原理提供了一些见解。
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