Subudhi Sumit K, Alegre Maria-Luisa, Fu Yang-Xin
Department of Pathology, University of Chicago, 5841 S. Maryland, Chicago, IL 60637, USA.
J Mol Med (Berl). 2005 Mar;83(3):193-202. doi: 10.1007/s00109-004-0617-1. Epub 2005 Jan 4.
Many of the B7 superfamily members (e.g., B7-1, B7-2, ICOS-L, B7-H1, B7-DC) were initially characterized as T cell costimulatory molecules. However, more recently it has become clear they can also coinhibit T cell responses. We review many of the B7 family members, with a particular focus on B7-H1, and examine their role in autoimmunity, transplant rejection, and cancer pathogenesis. It is crucial to understand that many B7 family members have opposing effects on an immune response. This cautions against using clinical immunotherapeutic reagents targeted against these molecules until we gain a better understanding of the circumstances that regulate the outcomes of the T cell response.
许多B7超家族成员（如B7-1、B7-2、ICOS-L、B7-H1、B7-DC）最初被鉴定为T细胞共刺激分子。然而，最近越来越清楚的是，它们也可以共抑制T细胞反应。我们综述了许多B7家族成员，特别关注B7-H1，并研究它们在自身免疫、移植排斥和癌症发病机制中的作用。必须明白，许多B7家族成员对免疫反应具有相反的作用。这提醒我们，在更好地了解调节T细胞反应结果的情况之前，谨慎使用针对这些分子的临床免疫治疗试剂。
