[严重急性呼吸综合征爆发期间对严重急性呼吸综合征患者密切接触者的血清学调查]
[Serological investigation on close contacts to patients with severe acute respiratory syndrome in an SARS outbreak].
作者信息
Xie Shu-yun, Zeng Guang, Chen Jiang-ting, Liu Yu-xuan, Li Shu-fen, Yin Wei-dong
机构信息
Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
出版信息
Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Oct;25(10):867-9.
OBJECTIVE
To study the evidence of severe acute respiratory syndrome (SARS) infection among close contacts to SARS patients and the level of sera IgG antibody in SARS cases.
METHODS
Specific IgG antibody against SARS-CoV in serum samples from contacts to patients, five months before an SARS outbreak in Beijing. Neutralized test, ELISA and immunity adherence test were studied. Samples were collected after clinical onset of patients or close contacts to patients, for 22 - 24 weeks. 19 close contacts and 13 cases were included in the study.
RESULTS
In close contacts, all tests were negative on three methods. All SARS cases were positive except one by immunity adherence test. The neutralized antibody levels were from 1:16 to 1:203, with medium level of 1:43.
CONCLUSION
According to our survey, there was no latent infection among close contacts. IgG antibody in sera continued to be at higher levels among SARS cases 22 - 24 weeks after onset.
目的
研究严重急性呼吸综合征（SARS）患者密切接触者中SARS感染证据及SARS病例血清IgG抗体水平。
方法
采集北京SARS疫情暴发前五个月患者密切接触者血清样本中针对SARS-CoV的特异性IgG抗体。研究中和试验、酶联免疫吸附测定（ELISA）和免疫黏附试验。在患者或患者密切接触者临床发病后22 - 24周采集样本。本研究纳入了19名密切接触者和13例病例。
结果
在密切接触者中，三种方法检测结果均为阴性。除1例通过免疫黏附试验检测为阴性外，所有SARS病例检测均为阳性。中和抗体水平为1:16至1:203，中位水平为1:43。
结论
根据我们的调查，密切接触者中无潜伏感染。发病后22 - 24周，SARS病例血清中的IgG抗体水平持续较高。
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