Jellison Evan R, Kim Sung-Kwon, Welsh Raymond M
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
J Immunol. 2005 Jan 15;174(2):614-8. doi: 10.4049/jimmunol.174.2.614.
Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.
II类限制性CD4 T细胞介导的靶细胞杀伤作用此前已在体外得到证实，但尚未在体内得到证实。在本研究中，我们使用一种以表达II类分子的B细胞为靶标的体内细胞毒性试验，在淋巴细胞性脉络丛脑膜炎病毒感染的小鼠体内证明了CD4依赖性MHC II类限制性杀伤作用。
