Jenssen Håvard, Gutteberg Tore J, Lejon Tore
Department of Medical Microbiology, University Hospital of North Norway, N-9038 Tromsø, Norway.
J Pept Sci. 2005 Feb;11(2):97-103. doi: 10.1002/psc.604.
Herpes simplex virus (HSV) causes a number of diseases and new therapies are being pursued vigorously. Earlier studies have shown that modified peptides based on lactoferricins reduce HSV-1 and HSV-2 infection, and structure-activity studies indicate that the anti-viral activity correlates with the binding affinity for heparan sulphate and chondroitin sulphate. In this study it is shown that theoretically derived amino acid descriptors can be used to model the anti-viral activity of peptides, as well as other peptide properties, even more accurately.
单纯疱疹病毒（HSV）会引发多种疾病，目前人们正在大力探索新的治疗方法。早期研究表明，基于乳铁传递蛋白的修饰肽可减少HSV - 1和HSV - 2感染，结构 - 活性研究表明，抗病毒活性与对硫酸乙酰肝素和硫酸软骨素的结合亲和力相关。在本研究中表明，理论推导的氨基酸描述符可用于更准确地模拟肽的抗病毒活性以及其他肽的特性。
