Gerschenson L E, Rotello R J
Department of Pathology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262.
FASEB J. 1992 Apr;6(7):2450-5. doi: 10.1096/fasebj.6.7.1563596.
Apoptosis is a type of cell death that plays an important role in early development and growth of normal adult tissues. It is regulated by physiological stimuli and is present in many species and tissues. The main morphological characteristics are nuclear fragmentation and cellular breakdown in apoptotic vesicles. Internucleosomal DNA fragmentation is an important biochemical feature that is the result of a yet to be isolated endonuclease activity. Experiments using RNA and protein synthesis inhibitors suggest the presence of either intracellular repressors or inducers of apoptosis.
细胞凋亡是一种细胞死亡类型，在正常成年组织的早期发育和生长中发挥着重要作用。它受生理刺激调控，存在于许多物种和组织中。主要形态学特征是细胞核碎片化和凋亡小体中的细胞解体。核小体间DNA碎片化是一个重要的生化特征，是一种尚未分离的核酸内切酶活性的结果。使用RNA和蛋白质合成抑制剂的实验表明存在细胞内凋亡抑制因子或诱导因子。
