Chaaba Raja, Attia Nebil, Hammami Sonia, Smaoui Maha, Mahjoub Sylvia, Hammami Mohamed, Masmoudi Ahmed Slaheddine
Biochemistry laboratory, UR 08-39, Faculty of Medicine MONASTIR, Tunisia.
Lipids Health Dis. 2005 Jan 6;4:1. doi: 10.1186/1476-511X-4-1.
Apolipoprotein A-V (Apo A-V) gene has recently been identified as a new apolipoprotein involved in triglyceride metabolism. A single nucleotide polymorphism (SNP3) located in the gene promoter (-1131) was associated with triglyceride variation in healthy subjects. In type 2 diabetes the triglyceride level increased compared to healthy subjects. Hypertriglyceridemia is a risk factor for coronary artery disease. We aimed to examine the interaction between SNP3 and lipid profile and coronary artery disease (CAD) in Tunisian type 2 diabetic patients.
The genotype frequencies of T/T, T/C and C/C were 0.74, 0.23 and 0.03 respectively in non diabetic subjects, 0.71, 0.25 and 0.04 respectively in type 2 diabetic patients. Triglyceride level was higher in heterozygous genotype (-1131 T/C) of apo A-V (p = 0.024). Heterozygous genotype is more frequent in high triglyceride group (40.9%) than in low triglyceride group (18.8%); p = 0.011. Despite the relation between CAD and hypertriglyceridemia the SNP 3 was not associated with CAD.
In type 2 diabetic patients SNP3 is associated with triglyceride level, however there was no association between SNP3 and coronary artery disease.
载脂蛋白A-V（Apo A-V）基因最近被确定为一种参与甘油三酯代谢的新载脂蛋白。位于该基因启动子（-1131）处的单核苷酸多态性（SNP3）与健康受试者的甘油三酯变化有关。2型糖尿病患者的甘油三酯水平相比健康受试者有所升高。高甘油三酯血症是冠状动脉疾病的一个危险因素。我们旨在研究突尼斯2型糖尿病患者中SNP3与血脂谱及冠状动脉疾病（CAD）之间的相互作用。
在非糖尿病受试者中，T/T、T/C和C/C基因型频率分别为0.74、0.23和0.03；在2型糖尿病患者中，分别为0.71、0.25和0.04。载脂蛋白A-V的杂合基因型（-1131 T/C）的甘油三酯水平更高（p = 0.024）。高甘油三酯组中杂合基因型的频率（40.9%）高于低甘油三酯组（18.8%）；p = 0.011。尽管CAD与高甘油三酯血症有关，但SNP3与CAD无关。
在2型糖尿病患者中，SNP3与甘油三酯水平有关，然而SNP3与冠状动脉疾病之间并无关联。
