De Queirós Laurinda, Castro Luis, Ferreira Maria Carmo, Gonçalves Guilherme
Centro Regional de Saúde Pública do Norte, Porto.
Acta Med Port. 2004 Jan-Feb;17(1):49-53. Epub 2004 Feb 27.
The new conjugate vaccines against group C meningococcal infection and pneumococcal infection were introduced in Portugal in 2001. In 2001/2002, the media published several alarming news on meningococcal disease and there was an increased demand of those vaccines, not included in the Portuguese National Vaccination Programme. In order to assess the coverage with these new vaccines against Neisseria meningitidis and Streptococcus pneumoniae, we conducted a descriptive study of the cohort born in 1999, using a convenience sample, from eight health centres in the North of Portugal. Data was collected from the vaccination records of 1877 children born in 1999: 37.2% had received the group C meningococcal conjugate vaccine and 33.3% the pneumococcal conjugate vaccine, while 21,2% had received both. Most vaccinations with pneumococcal conjugate vaccine were performed after 23 months of age, above the recommended age range. The biggest number of group C meningococcal conjugate vaccines given in a month, was recorded in February of 2002, when the maximum number of reported cases of meningococcal disease was also observed. Correlation of both distributions over time was very high (R(2)=0.95). In February 2002 the number of pneumococcal conjugate vaccine doses given rose again, after having been decreasing since October 2001. This study suggested research hypothesis for the future.
2001年，针对C群脑膜炎球菌感染和肺炎球菌感染的新型结合疫苗在葡萄牙投入使用。在2001/2002年，媒体发布了几则关于脑膜炎球菌病的警示新闻，对这些未被纳入葡萄牙国家疫苗接种计划的疫苗的需求有所增加。为了评估这些针对脑膜炎奈瑟菌和肺炎链球菌的新型疫苗的接种覆盖率，我们使用便利抽样法，对1999年出生的队列进行了描述性研究，该队列来自葡萄牙北部的八个健康中心。从1999年出生的1877名儿童的疫苗接种记录中收集数据：37.2%的儿童接种了C群脑膜炎球菌结合疫苗，33.3%接种了肺炎球菌结合疫苗，21.2%的儿童两种疫苗都接种了。大多数肺炎球菌结合疫苗的接种是在23个月龄之后进行的，超出了推荐的年龄范围。2002年2月记录到一个月内接种C群脑膜炎球菌结合疫苗的数量最多，当时也观察到脑膜炎球菌病报告病例数最多。两种疫苗接种量随时间的分布相关性非常高（R(2)=0.95）。在2002年2月，肺炎球菌结合疫苗的接种剂量在自2001年10月以来一直下降之后再次上升。本研究为未来提出了研究假设。
