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[毛霉病]

[Mucormycosis].

作者信息

Naftali M, Naftali M, Vered I, Garzuzi H

机构信息

Dept. of Ophthalmology, Central Hospital of the Emek, Afula.

出版信息

Harefuah. 1992 Feb 16;122(4):223-6.

PMID:1563682
Abstract

Mucormycosis, which is caused by a group of fungi found in rotting fruit and vegetables, can be fatal. The fungi do not cause disease in healthy individuals, but attack those with immunodepression. The usual patient is a diabetic in ketoacidosis, but also those with other causes of metabolic acidosis, such as AIDS, burns, and gastrointestinal tract ulcers, may be affected. When the disease results in infection of the sinuses, the patient may present with orbital apex syndrome: exophthalmos, IInd, IIIrd, IVth and VIth nerve involvement, conjunctival chemosis and central artery or vein occlusion. The presence of necrotic tissue in the nose should alert the physician to the possibility of mucormycosis. Prognosis is poor if it spreads to the brain or cavernous sinus and if treatment does not include surgery. We present 3 typical cases: a 71-year-old women and men aged 62 and 73, respectively. The first 2 died soon after the diagnosis was established. They had been conservatively treated and the disease had spread to the brain. The third survived after several months of treatment which included surgical debridement.

摘要

毛霉病由存在于腐烂水果和蔬菜中的一组真菌引起,可能致命。这些真菌在健康个体中不会引发疾病,但会侵袭免疫功能低下者。常见患者是患有酮症酸中毒的糖尿病患者,不过其他导致代谢性酸中毒的患者,如艾滋病患者、烧伤患者和胃肠道溃疡患者,也可能受到影响。当疾病导致鼻窦感染时,患者可能会出现眶尖综合征:眼球突出、第二、第三、第四和第六脑神经受累、结膜水肿以及中央动脉或静脉阻塞。鼻子中出现坏死组织应提醒医生注意毛霉病的可能性。如果扩散到大脑或海绵窦且治疗不包括手术,预后很差。我们呈现3个典型病例:分别为一名71岁女性和两名年龄分别为62岁和73岁的男性。前两例在确诊后不久死亡。他们接受了保守治疗,疾病已扩散至大脑。第三例在包括手术清创在内的数月治疗后存活下来。

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