Reinisch J M, Sanders S A
Kinsey Institute for Research in Sex, Gender, and Reproduction, Indiana University, Bloomington 47405.
Horm Behav. 1992 Mar;26(1):62-75. doi: 10.1016/0018-506x(92)90032-q.
Ten males exposed to diethylstilbestrol (DES), a nonsteroidal synthetic estrogen, during gestation were compared to their matched, unexposed brothers on measures of brain hemispheric specialization for processing nonlinguistic spatial information and cognitive abilities. DES exposure was associated with reduced hemispheric laterality and lowered spatial ability. These data provide direct evidence of a relationship between brain laterality, spatial cognitive ability, and prenatal exposure to hormones in human males. Further, the implications of these findings for understanding sexual differentiation of the human brain are discussed.
将10名在孕期接触过己烯雌酚（DES，一种非甾体合成雌激素）的男性与其未接触过该物质的匹配兄弟，在处理非语言空间信息和认知能力的大脑半球特化测量方面进行了比较。接触DES与半球偏侧性降低和空间能力下降有关。这些数据为男性大脑的半球偏侧性、空间认知能力与产前激素暴露之间的关系提供了直接证据。此外，还讨论了这些发现对理解人类大脑性别分化的意义。
