需要特定的刺激序列来诱导小鼠巨噬细胞合成抗菌分子一氧化氮。
A specific sequence of stimulation is required to induce synthesis of the antimicrobial molecule nitric oxide by mouse macrophages.
作者信息
Lorsbach R B, Russell S W
机构信息
Wilkinson Laboratory of the Cancer Center, University of Kansas Medical Center, Kansas City 66160.
出版信息
Infect Immun. 1992 May;60(5):2133-5. doi: 10.1128/iai.60.5.2133-2135.1992.
Abstract
Nitric oxide production by macrophages required either simultaneous or sequential exposure to gamma interferon and lipopolysaccharide; exposure to lipopolysaccharide followed by exposure to gamma interferon gave little response. The apparently evanescent nature of the lipopolysaccharide signal, necessitating persistent stimulation, could be essential to down-regulating nitric oxide production after bacteria are cleared in vivo.
摘要
巨噬细胞产生一氧化氮需要同时或先后暴露于γ干扰素和脂多糖；先暴露于脂多糖再暴露于γ干扰素几乎没有反应。脂多糖信号明显短暂的特性，需要持续刺激，这对于在体内清除细菌后下调一氧化氮的产生可能至关重要。
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