Kappel Joseph C, Barany George
Department of Chemistry, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, Minnesota 55455, USA.
J Comb Chem. 2005 Jan-Feb;7(1):78-84. doi: 10.1021/cc049949y.
Methionine has been used to anchor amines to polymeric supports for solid-phase synthesis. Either a "preformed handle" or a stepwise elongation strategy was followed. Cyanogen bromide (CNBr) treatment then released amines into solution. CNBr reaction variables were evaluated in order to converge to optimal cleavage conditions, and the strategy was shown to be effective for a range of primary and secondary amines, but not for aromatic amines.
甲硫氨酸已被用于将胺类连接到聚合物载体上以进行固相合成。采用了“预制手柄”或逐步延长策略。然后用溴化氰（CNBr）处理将胺类释放到溶液中。对CNBr反应变量进行了评估，以确定最佳裂解条件，结果表明该策略对一系列伯胺和仲胺有效，但对芳香胺无效。
