Lewkow L M, Hooker J L, Movahed A
Department of Medicine, East Carolina University School of Medicine, Greenville, NC 27858-4354.
Int J Cardiol. 1992 Mar;34(3):273-6. doi: 10.1016/0167-5273(92)90024-w.
Fifteen women with metastatic breast cancer undergoing autologous bone marrow transplantation were treated with an intensive induction regimen including cyclophosphamide and mitoxantrone in a phase I-II study. The cardiotoxicity of these two drugs in combination have not been previously reported. Three patients developed deeply inverted T-waves during or shortly following conclusion of high-dose chemotherapy with associated declines in ejection fraction of 0.04, 0.19 and 0.27. One patient developed a brief episode of congestive heart failure which resolved with supportive care. These three patients were the only ones to have received previous left chest wall radiotherapy during the course of their disease, prior to treatment with autologous bone marrow rescue. No patient developed dysrhythmia or QRS changes during a mean hospital stay of 33.7 days (range 27-40 days).
在一项I-II期研究中，15例接受自体骨髓移植的转移性乳腺癌女性患者接受了包括环磷酰胺和米托蒽醌的强化诱导方案治疗。此前尚未有这两种药物联合使用时心脏毒性的报道。3例患者在大剂量化疗期间或结束后不久出现深倒置T波，射血分数分别下降0.04、0.19和0.27。1例患者出现短暂的充血性心力衰竭发作，经支持治疗后缓解。这3例患者是在疾病过程中、接受自体骨髓挽救治疗之前仅有的接受过左胸壁放疗的患者。在平均33.7天（范围27 - 40天）的住院期间，没有患者出现心律失常或QRS波改变。
