Ovesná Z, Vachálková A, Horváthová K, Tóthová D
Cancer Research Institute, Slovak Academy of Sciences, 833 91 Bratislava, Slovak Republic.
Neoplasma. 2004;51(5):327-33.
Ursolic acid and oleanolic acid are pentacyclic triterpenoic acids having a similar chemical structure and are the major components of some oriental and traditional medicine herbs wildly distributed all over the world. There is a growing interest in the elucidation of the biological roles of both these triterpenoid compounds. This review summarizes the biological activities of presented triterpenoid acids (anti-inflammatory, hepatoprotective, gastroprotective, anti-ulcer, anti-HIV, cardiovascular, hypolipidemic, antiatherosclerotic and immunoregulatory effects). Our interest has been focussed especially on their anti-tumor and chemopreventive activity. Both compounds have been shown to act at various stages of tumor development, including inhibition of tumorigenesis, inhibition of tumor promotion, and induction of tumor cell differentiation. They effectively inhibit angiogenesis, invasion of tumor cells and metastasis. However, the mechanisms by which they act are poorly understood. Ursolic acid and oleanolic acid are relatively non-toxic and could be use as chemopreventive/chemoprotective agents in clinical praxis.
熊果酸和齐墩果酸是具有相似化学结构的五环三萜酸，是一些广泛分布于世界各地的东方和传统草药的主要成分。人们对阐明这两种三萜类化合物的生物学作用越来越感兴趣。本综述总结了上述三萜酸的生物学活性（抗炎、保肝、胃保护、抗溃疡、抗HIV、心血管、降血脂、抗动脉粥样硬化和免疫调节作用）。我们的兴趣尤其集中在它们的抗肿瘤和化学预防活性上。这两种化合物已被证明在肿瘤发展的各个阶段都有作用，包括抑制肿瘤发生、抑制肿瘤促进和诱导肿瘤细胞分化。它们能有效抑制血管生成、肿瘤细胞侵袭和转移。然而，它们的作用机制尚不清楚。熊果酸和齐墩果酸相对无毒，可在临床实践中用作化学预防/化学保护剂。
