巨噬细胞白细胞介素-12、白细胞介素-10与一氧化氮分泌在其杀肿瘤活性表达中的相互关系。
Interrelationship between macrophage IL-12, IL-10 and NO secretion in expression of their tumoricidal activity.
作者信息
Kozłowska K, Cichorek M, Zareczna M
机构信息
Department of Embryology, Medical University, 80-211 Gdansk, Poland.
出版信息
Neoplasma. 2004;51(6):465-70.
Peritoneal macrophage activity in the secretion of IL-12, IL-10, NO and interrelationship between these substances in hamster bearing two lines of transplantable melanomas with different biological properties were studied. It has been found that these macrophages lack of homogenous reactivity in the secretion of studied substances. Melanotic melanoma line evoked moderate increase secretion of all above mentioned substances, whereas amelanotic melanoma line, tumor with higher immunogenicity, tumorogenicity and with shorter survival time of animals induced considerably increase of IL-12 and NO with prominent decrease of IL-10 secretion. Results allow to assume that macrophage secretory activity and interrelationship between these substances is not uniform in two lines of the same neoplasma and that it depends on tumor biological properties. Such observation seems to be useful in case of tumor cytokine immunotherapy.
研究了携带两株具有不同生物学特性的可移植黑色素瘤的仓鼠腹腔巨噬细胞分泌白细胞介素-12（IL-12）、白细胞介素-10（IL-10）、一氧化氮（NO）的活性以及这些物质之间的相互关系。结果发现，这些巨噬细胞在分泌所研究物质时缺乏一致的反应性。黑色素性黑色素瘤株引起上述所有物质分泌适度增加，而无黑色素性黑色素瘤株，即具有较高免疫原性、致瘤性且动物存活时间较短的肿瘤，诱导IL-12和NO显著增加，同时IL-10分泌明显减少。结果表明，同一肿瘤的两株细胞中巨噬细胞的分泌活性以及这些物质之间的相互关系并不一致，且取决于肿瘤的生物学特性。这种观察结果在肿瘤细胞因子免疫治疗中似乎很有用。
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