Rehmann A, Müller D, Krumbiegel P, Herbarth O, Handrick W, Borte M, Diez U, Richter T
Klinik und Poliklinik für Kinder und Jugendliche der Universität Leipzig.
Klin Padiatr. 2005 Jan-Feb;217(1):15-7. doi: 10.1055/s-2004-816247.
With the (13)C-urea-breath test, 6.6 % of 3 372 preschool children of the Leipzig area tested H. pylori positive in 1998.
In 2000, 5.6 % of 3 854 grade-two pupils of the same area tested positive.
2 235 children participated in both tests campaigns. Therefore, their H. pylori state could be reinvestigated after two years.
30 of the 104 children, who were tested positive in 1998 were negative in 2000. Using questionnaires completed by the corresponding parents and family physicians, possible reasons of individual elimination were analysed. It was found that 18 of the 25 children received a H. pylori triple therapy. Three children had been tested false-positive in 1998. Four children received antibiotics for other reasons and H. pylori was obviously eradicated too. Only three children were not treated with any antibiotics between 1998 and 2000. For these children, spontaneous elimination is assumed.
Conclusions about spontaneous elimination of H. pylori infections are problematic. Further investigations are needed in consideration of this object.
1998年，在莱比锡地区3372名学龄前儿童中，采用（13）C - 尿素呼气试验检测，幽门螺杆菌阳性率为6.6%。
2000年，在同一地区3854名二年级学生中，5.6%检测呈阳性。
2235名儿童参与了这两次检测活动。因此，两年后对他们的幽门螺杆菌感染状况进行了再次调查。
1998年检测呈阳性的104名儿童中，有30名在2000年呈阴性。通过相应家长和家庭医生填写的问卷，分析了个体清除感染的可能原因。发现25名儿童中有18名接受了幽门螺杆菌三联疗法。3名儿童在1998年检测为假阳性。4名儿童因其他原因使用了抗生素，幽门螺杆菌也明显被清除。1998年至2000年期间只有3名儿童未使用任何抗生素。对于这些儿童，推测为自然清除。
关于幽门螺杆菌感染自然清除的结论存在问题。针对这一问题需要进一步研究。
