Klein Ronald, Klein Barbara E K, Moss Scot E
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 610 North Walnut Street, 4th Floor WARF, Madison, WI 53726-2336, USA.
J Diabetes Complications. 2005 Jan-Feb;19(1):35-41. doi: 10.1016/j.jdiacomp.2003.12.005.
The purpose of this report is to examine the overall 10-year incidence of erectile dysfunction and its relationships to other characteristics in men with younger onset diabetes.
In a population-based cohort study in southern Wisconsin, a 10-year cumulative incidence of reported erectile dysfunction was obtained in men who were 21 years of age or older, were less than 30 years of age at diagnosis of diabetes, had 10 or more years of diabetes, and were taking insulin (n=264).
Twenty-five percent developed erectile dysfunction. The incidence of erectile dysfunction increased with age (from 10.2% in those 21-29 years of age to 48.6% in those 40 years of age or older, P<.0001) and with increasing duration of diabetes (from 16.0% in those with 11-14 years of diabetes at baseline to 38.2% in those with 25 or more years of diabetes, P=.01). In multivariate analyses, incidence of erectile dysfunction was associated with age [odds ratio (OR) 1.10, 95% confidence interval (CI), 1.06, 1.14], untreated hypertension (OR 5.01, 95% CI, 2.05, 12.27), and a history of smoking (OR 2.41, 95% CI, 1.09, 5.30) at baseline.
These data suggest that cessation of cigarette smoking and tighter control of blood pressure might prevent or delay the onset of erectile dysfunction in persons with type 1 diabetes.
本报告旨在研究年轻起病的糖尿病男性勃起功能障碍的总体10年发病率及其与其他特征的关系。
在威斯康星州南部的一项基于人群的队列研究中,获取了年龄在21岁及以上、糖尿病诊断时年龄小于30岁、患糖尿病10年或更长时间且正在接受胰岛素治疗的男性(n = 264)报告的勃起功能障碍的10年累积发病率。
25%的人出现了勃起功能障碍。勃起功能障碍的发病率随年龄增加(从21 - 29岁人群中的10.2%增至40岁及以上人群中的48.6%,P <.0001)以及糖尿病病程延长而增加(从基线时糖尿病病程11 - 14年人群中的16.0%增至糖尿病病程25年或更长时间人群中的38.2%,P =.01)。在多变量分析中,勃起功能障碍的发病率与年龄[比值比(OR)1.10,95%置信区间(CI),1.06,1.14]、未治疗的高血压(OR 5.01,95% CI,2.05,12.27)以及基线时的吸烟史(OR 2.41,95% CI,1.09,5.30)相关。
这些数据表明,戒烟和更严格地控制血压可能预防或延缓1型糖尿病患者勃起功能障碍的发生。