Johannes C B, Araujo A B, Feldman H A, Derby C A, Kleinman K P, McKinlay J B
New England Research Institutes, Watertown, Massachusetts, USA.
J Urol. 2000 Feb;163(2):460-3.
We estimated the incidence of erectile dysfunction in men 40 to 69 years old at study entry during an average 8.8-year followup, and determined how risk varied with age, socioeconomic status and medical conditions.
Data from a randomly sampled population based longitudinal study of Massachusetts men were analyzed. A total of 1,709 men completed the baseline interview during 1987 to 1989 and 1,156 survivors completed followup from 1995 to 1997. The analysis sample consisted of 847 men without erectile dysfunction at baseline and with complete followup information. Erectile dysfunction was assessed by discriminant analysis of 13 questions from a self-administered sexual function questionnaire and a single global self-rating question.
The crude incidence rate for erectile dysfunction was 25.9 cases per 1,000 man-years (95% confidence interval [CI] 22.5 to 29.9). The annual incidence rate increased with each decade of age and was 12.4 cases per 1,000 man-years (95% CI 9.0 to 16.9), 29.8 (24.0 to 37.0) and 46.4 (36.9 to 58.4) for men 40 to 49, 50 to 59 and 60 to 69 years old, respectively. The age adjusted risk of erectile dysfunction was higher for men with lower education, diabetes, heart disease and hypertension. Population projections for men 40 to 69 years old suggest that 17,781 new cases of erectile dysfunction in Massachusetts and 617,715 in the United States (white males only) are expected annually.
Although prevalence estimates and cross-sectional correlates of erectile dysfunction have recently been established, incidence estimates were lacking. Incidence is necessary to assess risk, and plan treatment and prevention strategies. The risk of erectile dysfunction was about 26 cases per 1,000 men annually, and increased with age, lower education, diabetes, heart disease and hypertension.
我们评估了研究开始时年龄在40至69岁男性在平均8.8年随访期间勃起功能障碍的发病率，并确定风险如何随年龄、社会经济地位和医疗状况而变化。
分析了来自马萨诸塞州男性基于人群的随机抽样纵向研究的数据。共有1709名男性在1987年至1989年期间完成了基线访谈，1156名幸存者在1995年至1997年期间完成了随访。分析样本包括847名基线时无勃起功能障碍且有完整随访信息的男性。勃起功能障碍通过对一份自我管理的性功能问卷中的13个问题和一个单一的总体自我评分问题进行判别分析来评估。
勃起功能障碍的粗发病率为每1000人年25.9例（95%置信区间[CI]22.5至29.9）。发病率随每十年年龄增长而增加，40至49岁、50至59岁和60至69岁男性的发病率分别为每1000人年12.4例（95%CI9.0至16.9）、29.8例（24.0至37.0）和46.4例（36.9至58.4）。教育程度较低、患有糖尿病、心脏病和高血压的男性勃起功能障碍的年龄调整风险较高。对40至69岁男性的人口预测表明，马萨诸塞州每年预计有17781例新的勃起功能障碍病例，美国（仅白人男性）每年预计有617715例。
虽然最近已经确定了勃起功能障碍的患病率估计值和横断面相关性，但缺乏发病率估计值。发病率对于评估风险以及规划治疗和预防策略是必要的。勃起功能障碍的风险约为每年每1000名男性26例，并且随年龄、较低的教育程度、糖尿病、心脏病和高血压而增加。
