Gupta Amit, Aragaki Corinne, Gotoh Momokazu, Masumori Naoya, Ohshima Shinichi, Tsukamoto Taiji, Roehrborn Claus G
Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9110, USA.
J Urol. 2005 Feb;173(2):503-6. doi: 10.1097/01.ju.0000148907.92910.4d.
We determined the relationship between serum prostate specific antigen (PSA) and indexes of prostate volume in Japanese men, and compared that relationship with the one in white men.
Data on a clinical cohort of 535 Japanese men with at least moderate lower urinary tract symptoms (LUTS) and clinical benign prostatic hyperplasia were examined. PSA, and total and transition zone prostate volume were related to age and linear regression analyses were performed to analyze the relationship between PSA and volume indexes.
The group of 535 men with a median age of 68 years had a median serum PSA of 1.5 ng/ml, and a median total and transition zone volume of 26.8 and 8.8 ml, respectively. PSA, total prostate volume and transition zone volume increased almost linearly with age. On univariate regression with age with each successive decade total prostate volume increased by 10.65% (95% CI 5.4 to 16.2), transition zone volume increased by 20.84% (95% CI 11.84 to 30.56) and the transition zone index increased by 3.1% (95% CI 1.66 to 4.57). On multivariate analysis the PSA-total prostate volume relationship was statistically independent of age. The study suggests that Japanese men might produce or release more PSA per unit prostate volume than white men.
Japanese men with LUTS and clinical benign prostatic hyperplasia but no evidence of prostate cancer might produce and/or release more PSA per unit prostate volume than white men. To our knowledge the cutoffs for PSA and prostate volume to predict the response to LUTS therapy and the development of complications in Japanese men are unknown. Future studies in Japanese men are needed to identify these cutoffs.
我们确定了日本男性血清前列腺特异性抗原（PSA）与前列腺体积指标之间的关系，并将该关系与白人男性的进行比较。
对535名患有至少中度下尿路症状（LUTS）且临床诊断为良性前列腺增生的日本男性临床队列数据进行研究。PSA、前列腺总体积和移行区体积与年龄相关，并进行线性回归分析以分析PSA与体积指标之间的关系。
535名男性的中位年龄为68岁，血清PSA中位数为1.5 ng/ml，前列腺总体积和移行区体积中位数分别为26.8 ml和8.8 ml。PSA、前列腺总体积和移行区体积几乎随年龄呈线性增加。在按年龄每连续十年进行的单变量回归中，前列腺总体积增加10.65%（95%可信区间5.4至16.2），移行区体积增加20.84%（95%可信区间11.84至30.56），移行区指数增加3.1%（95%可信区间1.66至4.57）。多变量分析显示，PSA与前列腺总体积的关系在统计学上独立于年龄。该研究表明，日本男性每单位前列腺体积可能比白人男性产生或释放更多的PSA。
患有LUTS且临床诊断为良性前列腺增生但无前列腺癌证据的日本男性，每单位前列腺体积可能比白人男性产生和/或释放更多的PSA。据我们所知，预测日本男性对LUTS治疗反应及并发症发生情况的PSA和前列腺体积临界值尚不清楚。需要对日本男性进行进一步研究以确定这些临界值。
