Paquette David W
Department of Periodontology, Center for Oral and Systemic Diseases, University of North Carolina at Chapel Hill, School of Dentistry, Chapel Hill, North Carolina, USA.
Compend Contin Educ Dent. 2004 Sep;25(9):681-2, 685-92; quiz 694.
Cardiovascular disease (CVD) and periodontitis are common chronic conditions, and the former remains a major contributor to human mortality. Recent attention has focused on a potential link between periodontal disease and CVD. Observational studies consistently indicate that people with destructive periodontitis may be 1.3 to 2 times more likely to have CVD. This association appears to be biologically plausible, and investigations in atherosclerosis animal models demonstrate larger atheroma sizes in animals infected with the periodontal pathogen, Porphyromonas gingivalis, compared with control animals. Although direct intervention data on the effects of periodontal therapy on CVD risk in patients are not currently available, indirect data suggest that mechanical periodontal therapy can decrease surrogate cardiovascular markers such as serum C-reactive protein. After a recent systematic review on the periodontal-cardiovascular link, a consensus panel concluded that patients and clinicians should be informed that periodontal therapy may prevent the onset or progression of CVD.
心血管疾病（CVD）和牙周炎是常见的慢性疾病，前者仍然是导致人类死亡的主要因素。最近，人们的注意力集中在牙周疾病与心血管疾病之间的潜在联系上。观察性研究一致表明，患有破坏性牙周炎的人患心血管疾病的可能性可能是其他人的1.3至2倍。这种关联在生物学上似乎是合理的，并且在动脉粥样硬化动物模型中的研究表明，与对照动物相比，感染牙周病原体牙龈卟啉单胞菌的动物的动脉粥样瘤尺寸更大。虽然目前尚无关于牙周治疗对患者心血管疾病风险影响的直接干预数据，但间接数据表明，机械性牙周治疗可以降低替代心血管标志物，如血清C反应蛋白。在最近一项关于牙周-心血管联系的系统评价之后，一个共识小组得出结论，应该告知患者和临床医生，牙周治疗可能会预防心血管疾病的发生或进展。
