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[碳相成分对类金刚石碳(DLC)血小板粘附的影响]

[Effects of carbon phase components on platelets adhesion for diamond like carbon (DLC)].

作者信息

Li Bogang, Yin Jie, Yin Guangfu, Na Juanjuan, Zheng Changqiong

机构信息

College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2004 Dec;21(6):905-9.

Abstract

In the present paper, adhesive test, morphology observation, classified counting and deformation index calculation of the platelets on seven DLC samples made by different processes were carried out after XPS analysis, respectively. Then the effects of carbon phase components on amounts and deformation index of the platelets adhered to the samples were investigated by using the analysis of T-type correlation degree in the grey system theory. It has been shown from results that the amounts and the deformation index of the platelets adhered to the DLC samples made by plasma source ion implantation-ion beam enhanced deposition (PSII-IBED) are obviously less than those of DLC samples made by plasma CVD. The correlation degrees (negative) between the DLC carbon phase and the amounts as well as the deformation index of platelets are much more than those of the other four carbon phase components; besides, larger correlation degrees (positive) only appear between the deformation index of platelets and the C-H carbon phase or C-O carbon phase. It has been indicated that: (1) the effect of DLC carbon phase on platelets adhesion is much greater than that of the other four carbon phase components, the key to improvement in the hemocompatibility of DLC is to increase the DLC carbon phase content; (2) it is necessary to restrain the form or decrease the C-H carbon phase content and C-O carbon phase content so as to control their promotive action on deformation of the platelets adhered to the surface of DLC; (3) using PSII-IBED process to prepare DLC is helpful to improving the hemocompatibility of DLC. These conclusions are essential for designing and improving the deposition process of DLC.

摘要

在本文中,对通过不同工艺制备的七个类金刚石碳(DLC)样品进行X射线光电子能谱(XPS)分析后,分别进行了血小板的粘附试验、形态观察、分类计数以及变形指数计算。然后,运用灰色系统理论中的T型关联度分析方法,研究了碳相成分对粘附在样品上的血小板数量和变形指数的影响。结果表明,通过等离子体源离子注入-离子束增强沉积(PSII-IBED)制备的DLC样品上粘附的血小板数量和变形指数明显低于通过等离子体化学气相沉积(CVD)制备的DLC样品。DLC碳相与血小板数量以及变形指数之间的关联度(负相关)远大于其他四种碳相成分;此外,仅在血小板变形指数与C-H碳相或C-O碳相之间出现较大的关联度(正相关)。结果表明:(1)DLC碳相对血小板粘附的影响远大于其他四种碳相成分,提高DLC血液相容性的关键在于增加DLC碳相含量;(2)有必要抑制C-H碳相和C-O碳相的形成或降低其含量,以控制它们对粘附在DLC表面的血小板变形的促进作用;(3)采用PSII-IBED工艺制备DLC有助于提高DLC的血液相容性。这些结论对于设计和改进DLC的沉积工艺至关重要。

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