Obłak Ewa, Lachowicz Tadeusz M, Luczyński Jacek, Witek Stanisław
Institute of Genetics and Microbiology, University of Wrocław, Przybyszewskiego 65/73, 51-148 Wrocław, Poland.
Cell Mol Biol Lett. 2004;9(4A):755-63.
A set of oxalates of alpha-dimethylamino fatty acids n-alkyl esters (MEM-ns and n-MEM-8s) and n-dodecyl-N,N-dimethylalaninate (DMAL-12s) were synthesized. Their activities on the growth, transport, and ATPases from the yeast Saccharomyces cerevisiae were compared. The compounds differ in the number of carbon atoms in their aliphatic chain and in the position of that chain in their molecular structure. The tested aminoesters with twelve carbon atoms (MEM-10s and DMAL-12s) appeared to have the highest level of activity. These drugs inhibited plasma membrane H+-ATPase, but no inhibition of mitochondrial ATPase was observed. Under nitrogen-derepressed conditions, the aminoesters inhibited amino acid uptake by yeast cells.
合成了一组α-二甲基氨基脂肪酸正烷基酯（MEM-ns和n-MEM-8s）和正十二烷基-N，N-二甲基丙氨酸酯（DMAL-12s）的草酸盐。比较了它们对酿酒酵母生长、转运和ATP酶的活性。这些化合物在脂肪链中的碳原子数及其在分子结构中的位置不同。测试的含十二个碳原子的氨基酯（MEM-10s和DMAL-12s）似乎具有最高的活性水平。这些药物抑制质膜H + -ATP酶，但未观察到对线粒体ATP酶的抑制作用。在氮去阻遏条件下，氨基酯抑制酵母细胞对氨基酸的摄取。
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