Kakourou T, Psychou F, Voutetakis A, Xaidara A, Stefanaki K, Dacou-Voutetakis C
First Department of Pediatrics, Athens University, Greece.
J Eur Acad Dermatol Venereol. 2005 Jan;19(1):30-4. doi: 10.1111/j.1468-3083.2004.01078.x.
The relationship between granuloma annularae (GA) and diabetes mellitus (DM) is controversial.
To investigate the relationship between multiple lesions of GA and carbohydrate metabolism in children.
Fifteen children (seven boys, eight girls, mean age 4.8 years) with five or more lesions of GA were evaluated. A personal and family history of DM or other autoimmune diseases was obtained and the glycaemic and insulin response during an oral glucose tolerance test (OGTT) was determined. Thirteen children with a negative personal and family history of DM served as controls for the OGTT and 100 other children as 'clinical controls'.
At the 30-min sampling of the OGTT the mean insulin values were comparable in GA children and controls (P=0.1), while the mean glucose values were significantly higher in GA children than in controls (P=0.005). All other insulin values during the OGTT were significantly lower in GA children than in controls, while all other glucose values were comparable in GA children and controls with all indices applied. Eleven out of 15 GA children had a positive family history of DM (73.3% vs. 16% of the clinical controls; P<0.0001).
Multiple lesions of GA in children are associated with significantly lower serum insulin values than in controls and mildly impaired glucose tolerance.
环状肉芽肿（GA）与糖尿病（DM）之间的关系存在争议。
研究儿童多发GA皮损与碳水化合物代谢之间的关系。
对15例有5处或更多GA皮损的儿童（7名男孩，8名女孩，平均年龄4.8岁）进行评估。获取其个人及家族DM或其他自身免疫性疾病史，并测定口服葡萄糖耐量试验（OGTT）期间的血糖和胰岛素反应。13例个人及家族DM史阴性的儿童作为OGTT的对照，另外100名儿童作为“临床对照”。
在OGTT的30分钟采样时，GA患儿和对照的平均胰岛素值相当（P = 0.1），而GA患儿的平均血糖值显著高于对照（P = 0.005）。OGTT期间GA患儿的所有其他胰岛素值均显著低于对照，而应用所有指标时，GA患儿和对照的所有其他血糖值相当。15例GA患儿中有11例有DM家族史阳性（73.3%，而临床对照为16%；P<0.0001）。
儿童多发GA皮损与血清胰岛素值显著低于对照及轻度糖耐量受损有关。
