SAGA亮相。

SAGA unveiled.

作者信息

Timmers H Th Marc, Tora Làszlò

机构信息

Laboratory for Physiological Chemistry, University Medical Centre-Utrecht, STR. 3.223, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

出版信息

Trends Biochem Sci. 2005 Jan;30(1):7-10. doi: 10.1016/j.tibs.2004.11.007.

DOI:10.1016/j.tibs.2004.11.007

PMID:15653319

Abstract

Transcriptional regulation in eukaryotes is intimately coupled to chromatin dynamics. The SAGA (Spt-Ada-Gcn5) histone acetyltransferase (HAT) complex of Saccharomyces cerevisiae is a multi-subunit co-factor for RNA polymerase II transcription. However, not all gene activation events require its intrinsic HAT activity. In addition, SAGA subunits can also restrict gene transcription. The recently published structural model from the laboratories of Fred Winston and Patrick Schultz of the SAGA complex provides a framework to rationalize these findings and to direct further investigation of this crucial transcriptional co-factor.

摘要

真核生物中的转录调控与染色质动态变化密切相关。酿酒酵母的SAGA（Spt-Ada-Gcn5）组蛋白乙酰转移酶（HAT）复合物是RNA聚合酶II转录的多亚基辅因子。然而，并非所有基因激活事件都需要其内在的HAT活性。此外，SAGA亚基也可以限制基因转录。弗雷德·温斯顿实验室和帕特里克·舒尔茨实验室最近发表的SAGA复合物结构模型提供了一个框架，以合理化这些发现并指导对这一关键转录辅因子的进一步研究。