接受猪异位心脏移植的狒狒的肌钙蛋白T水平。

Troponin T levels in baboons with pig heterotopic heart transplants.

作者信息

Kuwaki K, Knosalla C, Dor F J M F, Gollackner B, Tseng Y-L, Houser S, Cooper D K C

机构信息

Transplantation Biology Research Center, Massachusetts General Hospital, 13th Street, Boston, MA 02129, USA.

出版信息

J Heart Lung Transplant. 2005 Jan;24(1):92-4. doi: 10.1016/j.healun.2003.09.039.

DOI:10.1016/j.healun.2003.09.039

PMID:15653386

Abstract

Troponin T levels have been monitored in baboons (n = 8) undergoing pig heterotopic heart transplantation, and correlated with a decrease in graft contractions and graft survival. Pig heart graft survival was from 12 to 139 days (mean 45, median 33), and graft failure was associated with predominant thrombotic microangiopathy and ischemia, with focal hemorrhage, and edema. An increase in troponin T levels 5 to 6 days before graft failure correlated closely with diminished graft contractions. An increase in troponin T was a reliable indicator that graft dysfunction was occurring.

摘要

已对接受猪异位心脏移植的狒狒（n = 8）的肌钙蛋白T水平进行了监测，并将其与移植物收缩功能的降低和移植物存活情况相关联。猪心脏移植物的存活时间为12至139天（平均45天，中位数33天），移植物失败与主要的血栓性微血管病和缺血有关，伴有局灶性出血和水肿。移植物失败前5至6天肌钙蛋白T水平的升高与移植物收缩功能减弱密切相关。肌钙蛋白T水平升高是移植物功能障碍正在发生的可靠指标。