B-raf和一个B-raf假基因位于人类的7号染色体长臂上。
B-raf and a B-raf pseudogene are located on 7q in man.
作者信息
Sithanandam G, Druck T, Cannizzaro L A, Leuzzi G, Huebner K, Rapp U R
机构信息
Biological Carcinogenesis and Development Program, PRI/Dyncorp, Frederick Cancer Research and Development Center, Maryland 21702-1201.
出版信息
Oncogene. 1992 Apr;7(4):795-9.
The B-raf gene was localized to human chromosome region 7p11-7qter by Southern blot analysis of its segregation in a panel of rodent-human hybrids, using a B-raf cDNA clone. Chromosomal in situ hybridization refined the localization to 7q33-36. Analysis of genomic B-raf clones identified a B-raf pseudogene in addition to the active gene. Based on the chromosomal mapping data we conclude that the pseudogene is located near the active gene.
通过使用B-raf cDNA克隆对一组啮齿动物-人类杂交体中其分离情况进行Southern印迹分析，将B-raf基因定位到人类染色体区域7p11 - 7qter。染色体原位杂交将定位精确到7q33 - 36。对基因组B-raf克隆的分析表明，除了活性基因外还存在一个B-raf假基因。基于染色体定位数据，我们得出假基因位于活性基因附近的结论。
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