Sharma Naveen, Butterworth Jeffrey, Cooper Brian T, Tselepis C, Iqbal Tariq H
Division of Medical Sciences, University of Birmingham, Birmingham B15 2TH, UK.
Am J Gastroenterol. 2005 Jan;100(1):201-6. doi: 10.1111/j.1572-0241.2005.40152.x.
Iron is essential in health and well-being and its dysregulation is a common theme in disease. Recent advances in our understanding of the molecular biology underlying hemochromatosis and anemia has provided insight into the complex mechanisms implicated in iron metabolism. The proximal small bowel is the major site of iron absorption and, it is becoming increasingly clear that the regulation of this process involves the liver and, in particular, the hepatic antimicrobial peptide hepcidin. A number of studies have shown hepcidin to have an inhibitory function at the level of small bowel iron absorption, although its exact site of action remains to be elucidated. Clearly, identifying the target of hepcidin is of importance and is likely to lead to the development of therapeutic agents in the treatment of iron disorders.
铁对健康至关重要,其调节异常是疾病中的一个常见现象。我们对血色素沉着症和贫血背后分子生物学的最新认识进展,为深入了解铁代谢所涉及的复杂机制提供了线索。近端小肠是铁吸收的主要部位,并且越来越清楚的是,这一过程的调节涉及肝脏,尤其是肝脏抗菌肽铁调素。许多研究表明,铁调素在小肠铁吸收水平具有抑制功能,尽管其确切作用位点仍有待阐明。显然,确定铁调素的靶点很重要,并且可能会导致开发治疗铁紊乱的治疗药物。