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运用化学计量学方法处理的器官金属组学可用于测定可能作为雄性大鼠暴露于氧化铁纳米颗粒的标志物的元素。

Organ Metallome Processed with Chemometric Methods Enable the Determination of Elements that May Serve as Markers of Exposure to Iron Oxide Nanoparticles in Male Rats.

机构信息

Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow, Poland.

Jagiellonian University, Institute of Zoology and Biomedical Research, Krakow, Poland.

出版信息

Biol Trace Elem Res. 2020 Dec;198(2):602-616. doi: 10.1007/s12011-020-02104-z. Epub 2020 Mar 12.

DOI:10.1007/s12011-020-02104-z
PMID:32166562
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7561579/
Abstract

The systemic influence of iron oxide nanoparticles on the elemental homeostasis of key organs was examined in male rats. In tissues taken at different intervals from nanoparticles injection, the dynamics of elemental changes was analyzed. The organ metallome was studied using total reflection X-ray fluorescence. The obtained data were processed with advanced cluster and discriminant analyses-to classify the tissues according to their organs of origin and to distinguish accurately the nanoparticle-treated and normal rats. Additionally, in the case of liver and heart, it was possible to determine the elements of highest significance for different treatments, which may serve as markers of exposure to iron oxide nanoparticles.

摘要

研究了氧化铁纳米粒子对雄性大鼠关键器官元素动态平衡的系统影响。在注射纳米粒子后的不同时间点从组织中采集样本，分析元素变化的动态。使用全反射 X 射线荧光研究器官金属组。采用先进的聚类和判别分析对获得的数据进行处理，根据组织来源对组织进行分类，并准确区分经纳米粒子处理的大鼠和正常大鼠。此外，在肝脏和心脏的情况下，有可能确定对不同处理最具重要意义的元素，这些元素可以作为暴露于氧化铁纳米粒子的标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ab/7561579/93c0c9a6b261/12011_2020_2104_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ab/7561579/b73a8f6e1eba/12011_2020_2104_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ab/7561579/007f6dd54614/12011_2020_2104_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ab/7561579/d4d898cf8ceb/12011_2020_2104_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ab/7561579/93c0c9a6b261/12011_2020_2104_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ab/7561579/b73a8f6e1eba/12011_2020_2104_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ab/7561579/007f6dd54614/12011_2020_2104_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ab/7561579/d4d898cf8ceb/12011_2020_2104_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ab/7561579/93c0c9a6b261/12011_2020_2104_Fig4_HTML.jpg

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