Hüffmeier Ulrike, Traupe Heiko, Burkhardt Harald, Schürmeier-Horst Funda, Lascorz Jesus, Böhm Beate, Lohmann Jörg, Ständer Markward, Wendler Jörg, Kelsch Reinhard, Baumann Claudia, Küster Wolfgang, Wienker Thomas F, Reis André
Institute of Human Genetics, University Erlangen-Nuremberg, Nuremberg, Germany.
J Invest Dermatol. 2005 Jan;124(1):107-10. doi: 10.1111/j.0022-202X.2004.23571.x.
A DNA variant, rs734232, altering a RUNX1 binding site was recently reported as susceptibility allele at PSORS2 (17q25) in cohorts of psoriasis patients from the US. A testing of this variant in psoriasis patients from Germany did not confirm this association in 300 trios nor in two case-control studies with 281 patients with psoriasis vulgaris and 375 patients with psoriatic arthritis, respectively. These results fail to support rs734232 as a psoriasis susceptibility factor in German psoriasis patients.
最近有报道称，一种改变RUNX1结合位点的DNA变体rs734232是美国银屑病患者队列中PSORS2（17q25）的易感等位基因。在德国银屑病患者中对该变体进行检测，在300个三联体中以及分别在两项针对281例寻常型银屑病患者和375例银屑病关节炎患者的病例对照研究中均未证实这种关联。这些结果不支持rs734232作为德国银屑病患者的银屑病易感因素。
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