Korendowych Eleanor, McHugh Neil
Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, BA1 1RL Bath, United Kingdom.
Curr Rheumatol Rep. 2005 Aug;7(4):306-12. doi: 10.1007/s11926-005-0041-8.
The genetic factors that are associated with psoriatic arthritis (PsA) are intricately linked with those that predispose to psoriasis itself. The strongest association is with human leukocyte antigen-Cw*0602, although true susceptibility may lie with one of the neighboring genes along a disease-associated haplotype. There are a number of interesting candidate genes within the major histocompatibility complex (MHC) region with strong functional relevance that have been investigated in PsA. In addition, several areas outside the MHC complex have been highlighted as a result of genetic linkage studies in psoriasis. PsA is a complex, multifactorial disease where multiple genes are likely to influence disease susceptibility, severity, and clinical phenotype. The current evidence for genetic factors in psoriasis and PsA will be reviewed.
与银屑病关节炎（PsA）相关的遗传因素与引发银屑病本身的遗传因素错综复杂地联系在一起。最强的关联是与人类白细胞抗原-Cw*0602，尽管真正的易感性可能在于疾病相关单倍型上的相邻基因之一。在主要组织相容性复合体（MHC）区域内有许多具有强烈功能相关性的有趣候选基因，已在银屑病关节炎中进行了研究。此外，由于银屑病的遗传连锁研究，MHC复合体之外的几个区域也受到了关注。银屑病关节炎是一种复杂的多因素疾病，多个基因可能影响疾病易感性、严重程度和临床表型。本文将综述目前关于银屑病和银屑病关节炎遗传因素的证据。
