Lacombe Michel
Hôpital Beaujon, 92118 Clichy cedex.
Bull Acad Natl Med. 2004;188(5):767-78; discussion 778-9.
We report our experience of surgical treatment of arterial complications after renal transplantation, in 154 patients operated on between 1970 and 2003. The arterial complication was discovered during a routine post-transplant check-up, or when the patient developed clinical manifestations (arterial hypertension, impaired renal function, arterial symptoms in the lower limbs), or following a septic complication. The following lesions were surgically managed: mycotic aneurysms (N = 5), atherosclerotic aneurysms (N = 13) or obstructions (N = 11) of the aorta and iliac arteries, and stenoses of the artery supplying the grafted kidney (N = 125). The type of arterial repair depended on the complication. There were no postoperative deaths. Three thromboses occurred after reconstruction of a stenotic transplant artery (3/125, 2.4 %), leading to graft loss. During long-term follow-up, atherosclerotic lesions of the iliac arteries worsened below an aortic prosthesis in three patients who required repeated surgery. In two other patients, stenosis recurred on a transplant artery and required re-operation. In one patient, an aneurysm developed in a vein graft and was successfully replaced by an arterial autograft. Late deaths among atherosclerotic patients in this setting are usually due to cardiac causes. In all patients, late chronic rejection may lead to kidney loss and hemodialysis.
我们报告了1970年至2003年间接受手术治疗的154例肾移植术后动脉并发症患者的经验。动脉并发症是在移植后常规检查时发现的,或者是在患者出现临床表现(动脉高血压、肾功能损害、下肢动脉症状)时发现的,或者是在发生感染性并发症之后发现的。对以下病变进行了手术处理:主动脉和髂动脉的霉菌性动脉瘤(N = 5)、动脉粥样硬化性动脉瘤(N = 13)或阻塞(N = 11),以及移植肾供血动脉狭窄(N = 125)。动脉修复的类型取决于并发症情况。术后无死亡病例。在狭窄的移植动脉重建后发生了3例血栓形成(3/125,2.4%),导致移植肾丢失。在长期随访中,3例患者在主动脉假体下方髂动脉的动脉粥样硬化病变恶化,需要再次手术。另外2例患者移植动脉狭窄复发,需要再次手术。1例患者静脉移植物中出现动脉瘤,成功地用自体动脉移植物进行了替换。在这种情况下,动脉粥样硬化患者的晚期死亡通常是由心脏原因导致的。在所有患者中,晚期慢性排斥反应可能导致移植肾丢失和血液透析。