Zhong Yisheng, Ye Wen, Luo Xunda
The Department of Ophthalmology, Ruijin Hospital Affiliated Shanghai Second Medical University,Shanghai 200025, China.
Yan Ke Xue Bao. 2004 Dec;20(4):213-8.
To study the situation for the follow eye visual field defect of patients with severe visual field loss in 1 eye from chronic glaucoma,and to analyze the relative risk factors for visual field defect in such eyes.
The visual field defect scores of fellow eyes were calculated in 47 cases [primary chronic angle-closed glaucoma (PACG) 23 cases and primary open angle glaucoma (POAG) 24 cases] with severe visual field loss in 1 eye (visual field defect score > or = 12). The relations were analyzed between the visual field defect scores of fellow eyes and the visual acuity,the maximal and the mean intraocular pressure (IOP), ages, refraction, diagnosis, the last periods of glaucoma, gender and the anti-glaucoma surgery history. Spearman correlation analyse was used to estimated the correlation between the visual field defect scores of fellow eyes and the above factors.
In the fellow eyes of the 23 cases PACG, 4 cases showed no visual field defect (score 0),5 cases showed the mild visual field defect (score 1-5), 7 cases showed the moderate visual field defect (score 6-11), 7 cases showed the severe or end-stage visual field defect (score 12-20). In the fellow eyes of the 24 cases POAG, 4 cases showed the mild visual field defect (score 1-5), 9 cases showed the moderate visual field defect (score 6-11), 11 cases showed the severe or end-stage visual field defect (score 12-20). The visual field defect score of fellow eyes in the last periods more than or equal to 10 years PACG group was significantly larger than that in the last periods less than 10 years PACG group (Z=2.8380, P=0.0224). The visual field defect score of fellow eyes in the mean IOP more than 18 mmHg PACG group was significantly larger than that in the mean IOP less than or equal to 18 mmHg PACG group (Z=1.9174, P=0.0276). The visual field defect score of fellow eyes in the anti-glaucoma surgery history POAG group was significantly larger than that in the non-anti-glaucoma surgery history POAG group (Z= 2.2377, P=0.0252). The significant positive correlation was found between the visual field defect scores and the mean IOP of the fellow eyes in the PACG group (r=0.4763, P= 0.0216),and the significant negative correlation was found between the visual field defect score and the visual acuity of the fellow eyes in the PACG group (r=-0.4416, P= 0.0349).
Among the PACG with severe visual field loss in 1 eye, the visual field defect extent in the fellow eyes was related to the mean IOP, the last periods of PACG and the visual acuity of the fellow eyes. The visual field defect score was positively correlated with the mean IOP, and negatively correlated with the visual acuity of the fellow eyes.
研究慢性青光眼单眼严重视野缺损患者对侧眼的视野缺损情况，并分析此类眼视野缺损的相关危险因素。
计算47例单眼严重视野缺损（视野缺损评分≥12）患者（原发性慢性闭角型青光眼23例，原发性开角型青光眼24例）对侧眼的视野缺损评分。分析对侧眼视野缺损评分与视力、最大及平均眼压（IOP）、年龄、屈光状态、诊断类型、青光眼患病时间、性别及抗青光眼手术史之间的关系。采用Spearman相关分析评估对侧眼视野缺损评分与上述因素之间的相关性。
23例原发性慢性闭角型青光眼患者的对侧眼中，4例无视野缺损（评分为0），5例有轻度视野缺损（评分为1 - 5），7例有中度视野缺损（评分为6 - 11），7例有重度或终末期视野缺损（评分为12 - 20）。24例原发性开角型青光眼患者的对侧眼中，4例有轻度视野缺损（评分为1 - 5），9例有中度视野缺损（评分为6 - 11），11例有重度或终末期视野缺损（评分为12 - 20）。青光眼患病时间≥10年的原发性慢性闭角型青光眼组对侧眼的视野缺损评分显著高于患病时间＜10年的原发性慢性闭角型青光眼组（Z = 2.8380，P = 0.0224）。平均眼压＞18 mmHg的原发性慢性闭角型青光眼组对侧眼的视野缺损评分显著高于平均眼压≤18 mmHg的原发性慢性闭角型青光眼组（Z = 1.9174，P = 0.0276）。有抗青光眼手术史的原发性开角型青光眼组对侧眼的视野缺损评分显著高于无抗青光眼手术史的原发性开角型青光眼组（Z = 2.2377，P = 0.0252）。原发性慢性闭角型青光眼组对侧眼视野缺损评分与平均眼压之间存在显著正相关（r = 0.4763，P = 0.0216），与对侧眼视力之间存在显著负相关（r = -0.4416，P = 0.0349）。
在单眼严重视野缺损的原发性慢性闭角型青光眼患者中，对侧眼的视野缺损程度与平均眼压、原发性慢性闭角型青光眼患病时间及对侧眼视力有关。视野缺损评分与平均眼压呈正相关，与对侧眼视力呈负相关。
