冈比亚醇的全合成。

The total synthesis of gambierol.

作者信息

Johnson Henry W B, Majumder Utpal, Rainier Jon D

机构信息

Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.

出版信息

J Am Chem Soc. 2005 Jan 26;127(3):848-9. doi: 10.1021/ja043396d.

DOI:10.1021/ja043396d

PMID:15656618

Abstract

This communication describes the total synthesis of the marine polyether toxin, gambierol. This work couples our iterative C-glycoside/enol ether-olefin metathesis strategy to the subunits with a unique olefin metathesis/carbonyl olefination reaction to bring the subunits together.

摘要

本通讯报道了海洋聚醚毒素冈比亚醇的全合成。这项工作将我们的迭代C-糖苷/烯醇醚-烯烃复分解策略与亚基相结合，通过独特的烯烃复分解/羰基烯化反应将亚基连接在一起。