Kwon Do-Yeon, Lee Kiyoun, Park Hyeri, Kim Mi Jung, Hong Jiyong
Department of Chemistry, Duke University, Durham, NC 27708, United States.
Department of Chemistry, The Catholic University of Korea, Bucheon 14662, Republic of Korea.
Bioorg Med Chem Lett. 2018 Sep 1;28(16):2746-2750. doi: 10.1016/j.bmcl.2018.02.038. Epub 2018 Feb 19.
NF00659B is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strategy paves the way to a total synthesis of NF00659B for further biological studies.
NF00659B是一种具有强大抗结肠癌活性的新型α-吡喃二萜类天然产物。本文描述了一种立体选择性合成NF00659B的2,2-二甲基氧杂环庚醇核心的方法，该方法采用了一系列烯烃酯闭环复分解、环氧化和格氏加成反应。这一策略为NF00659B的全合成铺平了道路，以便进行进一步的生物学研究。
