Dornbusch H J, Strenger V, Kerbl R, Lackner H, Schwinger W, Sovinz P, Urban C
Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescence Medicine, Medical University of Graz, Austria.
Support Care Cancer. 2005 May;13(5):343-6. doi: 10.1007/s00520-004-0721-3. Epub 2005 Jan 19.
Procalcitonin (PCT) has been described as a marker of bacterial sepsis. However, little is known of its diagnostic value in fungal infections. We calculated the sensitivity of PCT for detection of invasive fungal infections (IFI) by analyzing 55 episodes of proven or probable IFI (three in our series, 52 reported in the recent literature). In the early phase of IFI, PCT was elevated in fewer than half of invasive candidiasis episodes and in only one patient (5.3%) with invasive aspergillosis. Due to low sensitivity and specificity, PCT adds little to the diagnosis of IFI.
降钙素原（PCT）已被描述为细菌性败血症的标志物。然而，其在真菌感染中的诊断价值却鲜为人知。我们通过分析55例确诊或疑似侵袭性真菌感染（IFI）病例（其中3例为我们系列报道，52例为近期文献报道）来计算PCT检测IFI的敏感性。在IFI的早期阶段，侵袭性念珠菌病发作中PCT升高的不到一半，侵袭性曲霉病患者中只有1例（5.3%）PCT升高。由于敏感性和特异性较低，PCT对IFI的诊断帮助不大。
