果蝇心脏和血细胞发育中的GATA因子。
GATA factors in Drosophila heart and blood cell development.
作者信息
Sorrentino Richard Paul, Gajewski Kathleen M, Schulz Robert A
机构信息
Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
出版信息
Semin Cell Dev Biol. 2005 Feb;16(1):107-16. doi: 10.1016/j.semcdb.2004.10.005.
GATA transcription factors comprise an evolutionarily conserved family of proteins that function in the specification and differentiation of various cell types during animal development. In this review, we examine current knowledge of the structure, expression, and function of the Pannier and Serpent GATA factors as they relate to cardiogenesis and hematopoiesis in the Drosophila system. We also assess the molecular and genetic characteristics of the Friend of GATA protein U-shaped, which serves as a regulator of Pannier and Serpent function in these two developmental processes.
GATA转录因子构成了一个进化上保守的蛋白质家族，在动物发育过程中参与多种细胞类型的特化和分化。在这篇综述中，我们研究了Pannier和Serpent GATA因子的结构、表达和功能的现有知识，因为它们与果蝇系统中的心脏发生和造血作用相关。我们还评估了GATA蛋白U-shaped的分子和遗传特征，它在这两个发育过程中作为Pannier和Serpent功能的调节因子。
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