LIM结构域蛋白在心脏和造血形态发生中的作用。

The Roles of the LIM Domain Proteins in Cardiac and Hematopoietic Morphogenesis.

作者信息

She Meihua, Tang Min, Jiang Tingting, Zeng Qun

机构信息

Department of Biochemistry and Molecular Biology, College of Hengyang Medical, University of South China, Hengyang, China.

Affiliated Nanhua Hospital, University of South China, Hengyang, China.

出版信息

Front Cardiovasc Med. 2021 Feb 11;8:616851. doi: 10.3389/fcvm.2021.616851. eCollection 2021.

DOI:10.3389/fcvm.2021.616851

PMID:33681304

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7928361/

Abstract

has been used as a model organism for study on development and pathophysiology of the heart. LIM domain proteins act as adaptors or scaffolds to promote the assembly of multimeric protein complexes. We found a total of 75 proteins encoded by 36 genes have LIM domain in by the tools of SMART, FLY-FISH, and FlyExpress, and around 41.7% proteins with LIM domain locate in lymph glands, muscles system, and circulatory system. Furthermore, we summarized functions of different LIM domain proteins in the development and physiology of fly heart and hematopoietic systems. It would be attractive to determine whether it exists a probable "LIM code" for the cycle of different cell fates in cardiac and hematopoietic tissues. Next, we aspired to propose a new research direction that the LIM domain proteins may play an important role in fly cardiac and hematopoietic morphogenesis.

摘要

已被用作研究心脏发育和病理生理学的模式生物。LIM结构域蛋白作为衔接子或支架，促进多聚体蛋白复合物的组装。我们通过SMART、FLY-FISH和FlyExpress工具发现，共有36个基因编码的75种蛋白质具有LIM结构域，且约41.7%具有LIM结构域的蛋白质位于淋巴腺、肌肉系统和循环系统中。此外，我们总结了不同LIM结构域蛋白在果蝇心脏和造血系统发育及生理学中的功能。确定在心脏和造血组织中不同细胞命运的循环是否存在可能的“LIM密码”将很有吸引力。接下来，我们希望提出一个新的研究方向，即LIM结构域蛋白可能在果蝇心脏和造血形态发生中发挥重要作用。