“阿尔茨海默病抑郁”操作性标准的临床应用
Clinical application of operationalized criteria for 'Depression of Alzheimer's Disease'.
作者信息
Rosenberg Paul B, Onyike Chiadi U, Katz Ira R, Porsteinsson Anton P, Mintzer Jacobo E, Schneider Lon S, Rabins Peter V, Meinert Curtis L, Martin Barbara K, Lyketsos Constantine G
机构信息
Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
出版信息
Int J Geriatr Psychiatry. 2005 Feb;20(2):119-27. doi: 10.1002/gps.1261.
OBJECTIVES
'Depression of Alzheimer's Disease' (dAD) is a common complication of Alzheimer's disease and is increasingly recognized as a syndrome with a clinical presentation differing from major depression. Criteria for the diagnosis of dAD have been proposed previously.
METHODS
This paper presents these criteria in operationalized format designed to be accessible for clinical use. Four cases are discussed that demonstrate the use of these criteria and illustrate important differences between dAD and major depression.
RESULTS
The dAD criteria are broader than DSM-IV criteria for Major Depressive Episode and incorporate caregiver input.
CONCLUSIONS
Given the differences between dAD and major depression diagnoses, it is important to assess the efficacy of treatments for dAD. Depression in Alzheimer's Disease-2 (DIADS-2) is a controlled trial of dAD treatments that will also assess the validity of these criteria.
目的
“阿尔茨海默病性抑郁”（dAD）是阿尔茨海默病的常见并发症，越来越被认为是一种临床表现不同于重度抑郁症的综合征。此前已提出dAD的诊断标准。
方法
本文以可用于临床的操作性形式呈现这些标准。讨论了四个病例，展示了这些标准的应用，并说明了dAD与重度抑郁症之间的重要差异。
结果
dAD标准比《精神疾病诊断与统计手册》第四版（DSM-IV）中重度抑郁发作的标准更宽泛，并纳入了照料者的意见。
结论
鉴于dAD与重度抑郁症诊断之间的差异，评估dAD治疗的疗效很重要。阿尔茨海默病抑郁-2（DIADS-2）试验是一项dAD治疗的对照试验，也将评估这些标准的有效性。
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