Khakoo Aarif Y, Finkel Toren
National Institutes of Health, National Heart, Lung, and Blood Institute, Cardiovascular Branch, Laboratory of Molecular Biology, Bethesda, Maryland 21284, USA.
Annu Rev Med. 2005;56:79-101. doi: 10.1146/annurev.med.56.090203.104149.
Endothelial progenitor cells are a circulating, bone marrow-derived cell population that appears to participate in both vasculogenesis and vascular homeostasis. Questions persist regarding their functional characteristics, as well as the precise panel of cell surface markers that uniquely define this newly described progenitor cell population. We review experimental results obtained from both animal studies and recent clinical trials that suggest this cell type may have tremendous therapeutic potential for a wide range of human diseases.
内皮祖细胞是一种循环的、源自骨髓的细胞群体，似乎参与血管生成和血管稳态维持。关于它们的功能特性以及独特定义这个新描述的祖细胞群体的精确细胞表面标志物组合，仍存在疑问。我们回顾了来自动物研究和近期临床试验的实验结果，这些结果表明这种细胞类型可能对多种人类疾病具有巨大的治疗潜力。
