Lazar Mitchell A
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6149, USA.
Science. 2005 Jan 21;307(5708):373-5. doi: 10.1126/science.1104342.
The epidemic of obesity-associated diabetes is a major crisis in modern societies, in which food is plentiful and exercise is optional. The biological basis of this problem has been explored from evolutionary and mechanistic perspectives. Evolutionary theories, focusing on the potential survival advantages of "thrifty" genes that are now maladaptive, are of great interest but are inherently speculative and difficult to prove. Mechanistic studies have revealed numerous fat-derived molecules and a link to inflammation that, together, are hypothesized to underlie the obesity-diabetes connection and thereby represent prospective targets for therapeutic intervention.
肥胖相关糖尿病的流行是现代社会面临的重大危机，在这些社会中食物丰富且运动并非必需。人们已从进化和机制的角度探索了这一问题的生物学基础。进化理论关注那些如今已不适应环境的“节俭”基因的潜在生存优势，虽备受关注，但本质上具有推测性且难以证明。机制研究揭示了众多脂肪衍生分子以及与炎症的关联，据推测，这些因素共同构成了肥胖与糖尿病之间联系的基础，因此有望成为治疗干预的靶点。
