模型在理解CD8 + T细胞记忆中的作用。
The role of models in understanding CD8+ T-cell memory.
作者信息
Antia Rustom, Ganusov Vitaly V, Ahmed Rafi
机构信息
Department of Biology, Emory University, Atlanta, Georgia 30322, USA.
出版信息
Nat Rev Immunol. 2005 Feb;5(2):101-11. doi: 10.1038/nri1550.
Immunological memory - the ability to 'remember' previously encountered pathogens and respond faster on re-exposure - is a central feature of the immune response of vertebrates. We outline how mathematical models have contributed to our understanding of CD8(+) T-cell memory. Together with experimental data, models have helped to quantitatively describe and to further our understanding of both the generation of memory after infection with a pathogen and the maintenance of this memory throughout the life of an individual.
免疫记忆——即“记住”先前遇到的病原体并在再次接触时更快做出反应的能力——是脊椎动物免疫反应的一个核心特征。我们概述了数学模型如何有助于我们对CD8(+) T细胞记忆的理解。与实验数据一起，模型有助于定量描述并加深我们对病原体感染后记忆的产生以及个体一生中这种记忆的维持的理解。
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