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左旋多巴/苄丝肼在家居环境下治疗不宁腿综合征六个月的疗效观察

[Six months treatment of restless legs syndrome with levodopa/benserazide in domiciliary practice].

作者信息

Mühlau G

出版信息

MMW Fortschr Med. 2004 Dec 9;146(Suppl 3-4):87-93.

Abstract

Restless legs syndrome is a common neurological condition with 2-10% prevalence in the general population. Patients suffer from uncomfortable or unpleasant sensations in legs or arms and motor restlessness with a compelling desire to move the extremities. The symptoms worsen at rest with at least temporary relief by activity but also later in the day and in the evening. Dopaminergic drugs are considered to be the first choice in therapy, however, only levodopa/benserazide is approved until now. In this six months observational study, eighty patients with diagnosed RLS were treated with levodopa/ benserazide. The RLS symptoms improved in 90%, 77.5% of the patients continued with the treatment after the end of the study. Levodopa/Benserazide proved to be efficacious independently of severity of RLS and was well tolerated in long-term therapy.

摘要

不宁腿综合征是一种常见的神经系统疾病,在普通人群中的患病率为2%至10%。患者会在腿部或手臂出现不舒服或不愉快的感觉,以及运动性不安,并有强烈的移动四肢的欲望。症状在休息时加重,活动至少能暂时缓解,但在一天的晚些时候和晚上也会加重。多巴胺能药物被认为是治疗的首选,然而,到目前为止只有左旋多巴/苄丝肼被批准使用。在这项为期六个月的观察性研究中,80名被诊断为不宁腿综合征的患者接受了左旋多巴/苄丝肼治疗。90%的患者不宁腿综合征症状得到改善,77.5%的患者在研究结束后继续接受治疗。左旋多巴/苄丝肼被证明对不宁腿综合征的严重程度具有独立疗效,并且在长期治疗中耐受性良好。

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