Kinge Einar, Lossius Morten Ingvar
Sandvika Nevrologpraksis, 1338 Sandvika.
Tidsskr Nor Laegeforen. 2004 Jan 8;124(1):25-7.
Restless legs syndrome is a common and not fully appreciated disorder. Improved treatment options require knowledge about the condition.
The article is based on a literature search on Medline, PubMed and Scirus for the years 1988-2003 with the keyword "restless legs".
Restless legs syndrome is a chronic condition defined as an irresistible desire to move one's limbs, usually associated with paraesthesia/dysaesthesia and motor restlessness. The symptoms start or worsen at rest and improve with activity. The prevalence is between 5% and 15%. 80% of patients suffer from periodic limb movements in sleep. A current hypothesis is that the condition results from a deficiency of iron that lead to the underlying dopaminergic abnormalities. Therapeutically, studies have confirmed the effect of levodopa and dopamine agonists; dopamine agonists seem to imply less risk of side effects.
不宁腿综合征是一种常见但尚未得到充分认识的疾病。改善治疗方案需要了解该病症。
本文基于1988 - 2003年在Medline、PubMed和Scirus上以“不宁腿”为关键词进行的文献检索。
不宁腿综合征是一种慢性病症，定义为肢体有难以抑制的活动欲望，通常伴有感觉异常/感觉障碍和运动性不安。症状在休息时开始或加重，活动后改善。患病率在5%至15%之间。80%的患者在睡眠中出现周期性肢体运动。目前的一种假说是，该病症是由铁缺乏导致潜在的多巴胺能异常引起的。在治疗方面，研究已证实左旋多巴和多巴胺激动剂的疗效；多巴胺激动剂似乎副作用风险较小。
