Ciprandi G, Milanese M, Tosca M A, Cirillo I, Vizzaccaro A, Ricca V
Allergologia, UO ORL, Dipartimento Testa Collo, Ospedale San Martino, Genova, Italy.
Eur Ann Allergy Clin Immunol. 2004 Dec;36(10):363-5.
BACKGROUND: Eosinophil inflammation is present in nasal and bronchial mucosa and a clear link between upper and lower airways exists. Our aim was to evaluate whether nasal inflammation correlates with lung function in patients with perennial allergic rhinitis associated with asthma. METHODS: Eighty perennial allergic rhinitics with mild asthma, aged from 18 to 46 years, were enrolled. Nasal scraping and spirometry were performed in all subjects. RESULTS: A close relationship between the nasal eosinophil number and the percentage of predicted FEV1 was demonstrated (r = -0.76; p<0.0001). CONCLUSIONS Nasal cytology may be considered a non-invasive tool to assess airway inflammation in mild asthmatics with associated allergic rhinitis.
背景：嗜酸性粒细胞炎症存在于鼻和支气管黏膜中，且上、下气道之间存在明确联系。我们的目的是评估常年性变应性鼻炎合并哮喘患者的鼻炎症与肺功能是否相关。 方法：纳入80例年龄在18至46岁之间的轻度哮喘常年性变应性鼻炎患者。对所有受试者进行鼻刮片检查和肺功能测定。 结果：鼻嗜酸性粒细胞数量与预计FEV1百分比之间存在密切关系（r = -0.76；p<0.0001）。 结论：鼻细胞学检查可被视为评估合并变应性鼻炎的轻度哮喘患者气道炎症的一种非侵入性工具。
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