白细胞黏附的氧化修饰

Oxidative modification of leukocyte adhesion.

作者信息

Ley Klaus, Deem Tracy L

机构信息

Cardiovascular Research Center and Departments of Biomedical Engineering, Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.

出版信息

Immunity. 2005 Jan;22(1):5-7. doi: 10.1016/j.immuni.2005.01.002.

DOI:10.1016/j.immuni.2005.01.002

PMID:15664154

Abstract

In this issue of Immunity, Marko Salmi and colleagues describe mice lacking AOC3, an endothelial cell monoaminooxidase that is involved in modulating leukocyte rolling, adhesion, and migration (Stolen et al., 2005). Their data demonstrate the importance of oxidative modification of (unknown) adhesion molecules in regulating inflammation and lymphocyte homing.

摘要

在本期《免疫》杂志中，马尔科·萨尔米及其同事描述了缺乏AOC3的小鼠，AOC3是一种参与调节白细胞滚动、黏附和迁移的内皮细胞单胺氧化酶（斯托伦等人，2005年）。他们的数据证明了（未知）黏附分子的氧化修饰在调节炎症和淋巴细胞归巢中的重要性。