结构域交换与逆转录病毒组装

Domain swapping and retroviral assembly.

作者信息

Kingston Richard L, Vogt Volker M

机构信息

Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.

出版信息

Mol Cell. 2005 Jan 21;17(2):166-7. doi: 10.1016/j.molcel.2005.01.002.

DOI:10.1016/j.molcel.2005.01.002

PMID:15664185

Abstract

The structure of a mammalian SCAN domain has been recently reported. The molecule is a structural homolog of the HIV-1 capsid protein and forms a domain-swapped dimer in solution. The authors propose a similar domain-swapping event facilitates HIV-1 assembly, providing a new model for protein-protein interactions underlying viral particle formation.

摘要

最近报道了一种哺乳动物扫描结构域的结构。该分子是HIV-1衣壳蛋白的结构同源物，在溶液中形成结构域交换二聚体。作者提出类似的结构域交换事件促进HIV-1组装，为病毒颗粒形成背后的蛋白质-蛋白质相互作用提供了一个新模型。