女性性别发育途径：卵巢胚胎发育的当前知识
The pathway to femaleness: current knowledge on embryonic development of the ovary.
作者信息
Yao Humphrey Hung-Chang
机构信息
Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, IL 61802, USA.
出版信息
Mol Cell Endocrinol. 2005 Jan 31;230(1-2):87-93. doi: 10.1016/j.mce.2004.11.003.
Abstract
Increasing evidence indicates that organogenesis of the ovary is not a passive process arising by default in the absence of the testis pathway. A coordinated interaction is actually in force between somatic cells and female germ cells in embryonic ovaries, thus creating a unique microenvironment that facilitates the formation of follicles. Identification of the functional roles of several novel regulatory elements such as Figalpha, Foxl2, follistatin, and Wnt4 reveals the complexity of early ovarian organization. Challenges await us to establish the molecular connections of these molecules as well as to discover new candidates in the pathway of early ovarian development.
摘要
越来越多的证据表明，卵巢的器官发生并非是在缺乏睾丸发育途径时默认出现的被动过程。实际上，胚胎卵巢中的体细胞与雌性生殖细胞之间存在着协同相互作用，从而形成了一个独特的微环境，有利于卵泡的形成。对Figalpha、Foxl2、卵泡抑素和Wnt4等几种新型调控元件功能作用的鉴定揭示了早期卵巢组织的复杂性。我们面临着诸多挑战，既要建立这些分子之间的分子联系，又要在早期卵巢发育途径中发现新的候选分子。
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