Molecular mechanisms of high level tetracycline-resistance in group A streptococcal isolates, T serotypes 4 and 11.
作者信息
Matsumoto Masakado, Sakae Kenji, Ohta Michio, Endo Miyoko, Okuno Rumi, Murayama Shoko, Hirasawa Kyoko, Suzuki Rieko, Isobe Junko, Tanaka Daisuke, Katsukawa Chihiro, Tamaru Aki, Tomita Masaaki, Ogata Kikuyo, Yasuoka Tomihisa, Ikebe Tadayoshi, Watanabe Haruo
机构信息
Department of Microbiology, Aichi Prefectural Institute of Public Health, Nagoya 462-8576, Japan.
出版信息
Int J Antimicrob Agents. 2005 Feb;25(2):142-7. doi: 10.1016/j.ijantimicag.2004.09.014.
The molecular mechanism of high level tetracycline resistance in T serotypes 4 and 11 group A streptococcal (GAS) isolates was examined in 61 tetracycline-resistant isolates in Japan. PCR and sequencing analyses revealed that the T serotype/emm genotype, T4/4 isolates carried tet(O) genes, which were genetically homogenous. The T11/11 and T11/89 isolates carried different subtypes of tet(M) genes, which were present on transposons Tn916 and Tn1545, respectively. In addition, these T11 isolates may have obtained the tet(M) gene after the 1990s, because resistance to tetracycline in T11 isolates was rarely found before then. These results strongly suggested that the T4 and T11 GAS isolates acquired tetracycline-resistance via different molecular mechanisms.
Zotero 插件