Almasanu Benjamin P, Owensby Jennifer R, Pavlakis Steven G, Edwards Jon H
Department of Pediatrics, Infants and Children's Hospital of Brooklyn, Maimonides Medical Center, 977 48th Street, Brooklyn, NY 11219, USA.
Pediatr Neurol. 2005 Feb;32(2):124-6. doi: 10.1016/j.pediatrneurol.2004.07.008.
We report a male with spinal cord infarction and tetraplegia after Streptococcus pneumoniae meningitis. He was subsequently found to have both a Chiari I malformation and factor V Leiden mutation. A literature search was conducted to identify previously reported cases of pediatric spinal cord infarction associated with acute bacterial meningitis, anatomic brain anomalies, and hypercoagulability disorders. This article is the first report of spinal cord infarction in a child with hypercoagulability disorder and structural brain anomaly in the setting of acute bacterial meningitis. The confluence of infection, inflammation, localized pressure, and predisposition to hypercoagulability produced unique conditions resulting in infarction of the cervical spine. This report emphasizes the polygenic nature of the expression of spinal cord infarction.
我们报告了一例男性患者，其在肺炎链球菌脑膜炎后发生脊髓梗死并出现四肢瘫痪。随后发现他同时患有Chiari I畸形和凝血因子V莱顿突变。我们进行了文献检索，以确定先前报道的与急性细菌性脑膜炎、脑部解剖异常和高凝性疾病相关的小儿脊髓梗死病例。本文是首例关于急性细菌性脑膜炎背景下患有高凝性疾病和结构性脑异常的儿童发生脊髓梗死的报告。感染、炎症、局部压迫和高凝倾向的共同作用产生了独特的情况，导致颈椎梗死。本报告强调了脊髓梗死表达的多基因性质。
